近三年论文 · 214 篇 （点击展开摘要，时间倒序）
Spatially Resolved Proteomic Cartography Illuminates the Earliest Molecular Programs in Pancreatic Cancer Evolution
Min, Schweizer, and colleagues use artificial intelligence-powered deep visual proteomics to generate a spatial proteomic atlas of pancreatic cancer precursor evolution, revealing that major metabolic and inflammatory reprogramming occurs long before overt histologic transformation. More broadly, the study highlights the emerging potential of spatial proteomics and multiomics to bridge histopathology with molecular pathology and precision oncology. See related article by Min et al., p. 1323.
Decoding Spatial Programs in Human Glioblastoma Through Surprisal Information-Theoretical Analysis
Abstract Glioblastoma (GBM) is a highly heterogeneous and invasive brain tumor in which complex interactions among tumor cells, immune cells, and neurons shape disease progression and therapeutic resistance. Resolving spatial patterns programs in glioblastoma (GBM) requires analytical approaches that go beyond variance-driven embeddings. Here, we applied thermodynamic surprisal analysis, an information-theoretic decomposition framework, to spatial transcriptomic sequencing from human GBM specimens to identify orthogonal constraint modes that capture dominant and previously hidden spatial programs. Surprisal analysis revealed structured patterns in the data that are not highlighted by standard approaches such as PCA or cell type deconvolution, including immune-activation–associated signatures as well as spatial programs consistent with synapse remodeling. Coupling surprisal decomposition with spatial ligand–receptor interaction analysis, NICHES, along with multiplexed protein imaging connected these spatial hidden modes to reveal potential communication networks. Together, these results position surprisal analysis as a powerful, complementary strategy for interrogating spatial tumor architecture, enabling discovery of non-obvious spatial programs and interactions that are obscured by variance-based methods.
3D multi-omics tumour atlases: from technology to biology and clinical translation
Histology data from the lymph node of a 52 year-old unknown female
Histology data from the lymph node of a 45 year-old unknown male
Histology data from the lymph node of a 27 year-old white female
Histology data from the lymph node of a 45 year-old unknown male
Histology data from the lymph node of a 31 year-old white female
Histology data from the lymph node of a 49 year-old white female
Histology data from the lymph node of a 7 year-old white male
Histology data from the lymph node of a 73 year-old white female
Histology data from the lymph node of a 49 year-old white female
Histology data from the lymph node of a 27 year-old white female
Histology data from the lymph node of a 43 year-old white female
Histology data from the lymph node of a 27 year-old white female
Histology data from the lymph node of a 64 year-old white male
Histology data from the lymph node of a 64 year-old asian female
Histology data from the lymph node of a 46 year-old black or african american female
Histology data from the lymph node of a 52 year-old unknown female
Histology data from the lymph node of a 14 year-old white male
Histology data from the lymph node of a 54 year-old black or african american female
Histology data from the lymph node of a 46 year-old black or african american female
Histology data from the lymph node of a 7 year-old white male
Histology data from the lymph node of a 55 year-old black or african american female
Histology data from the lymph node of a 52 year-old unknown female
Histology data from the lymph node of a 56 year-old white female
Histology data from the lymph node of a 62 year-old black or african american male
Histology data from the lymph node of a 27 year-old white female
Histology data from the lymph node of a 64 year-old asian female
Histology data from the lymph node of a 14 year-old white male
Histology data from the lymph node of a 52 year-old unknown female
Histology data from the lymph node of a 54 year-old black or african american female
Histology data from the lymph node of a 44 year-old black or african american male
Histology data from the lymph node of a 5 year-old white female
Histology data from the lymph node of a 55 year-old black or african american female
Histology data from the lymph node of a 14 year-old white male
Histology data from the lymph node of a 76 year-old white male
Histology data from the lymph node of a 14 year-old white male
Histology data from the lymph node of a 74 year-old white female
Histology data from the lymph node of a 52 year-old white female